Kris Kulp

Contact information

Lawrence Livermore National Laboratory

7000 East Avenue, L-452

Livermore, CA 94550

email: kulp2@llnl.gov

phone: 925 422-6351

Education

Post-Doctoral Fellow, Lawrence Livermore National Laboratory, 1997-2000

Post-Doctoral Fellow, University of California, Davis, 1995-1997

Ph.D., Pharmacology and Toxicology, University of California, Davis 1995

B.A., Chemistry, Knox College, Galesburg Il, 1983

 

Research interests

 

Toxicology, biotechnology development, and cancer biology.

I am the Group Leader for the Pharmacology and Toxicology Group and the Director of the LLNL Institutional Postdoc Program.  I joined LLNL as a postdoc to do research on the role of dietary carcinogens in the development of human cancer. Taking advantage of the laboratory’s wide opportunities for multi-disciplinary research, I teamed with physicist Kuang Jen Wu to expand my work to developing imaging mass spectrometry techniques for determining disease effects on single cells and tissues. Currently, I am the biology lead for the LLNL iChip (in vitro Chip-based Human Investigational Platform) project, which is developing a tissue-based assay system that models human physiological response. This platform will be used to accelerate the development of new drug entities and to study mechanisms of infection and disease, systems biology, inter- and intra-cellular communication and effectors of cellular growth and metabolism.

 

Most recent publications:

  1. B. Hudson, K.S. Kulp. G. Loots,” Prostate Cancer invasion and metastasis: Insights from mining genomic data” Briefings in Functional Genomics, 2013, 12(5), 397-410
  2. B.J. Stewart, A. Navid, K.S. Kulp, J.L.S. Knaack, G. Bench, “ D-Lactate production as a function of glucose metabolism in Saccharomyces CerevisiaeYeast, 2013, 30(2), 81-91
  3. B. A. Buchholz, M. J. Sarachine, B. J. Stewart, K. W. Haack, T. J. Ognibene, G. Bench, G. A. Salazar Quintero, M. A. Malfatti, K. S. Kulp, K. W. Turteltaub “Bioanalytics for Human Microdosing” in The Encyclopedia of Drug Metabolism and Interactions, Vol. 5, Chapter 21
  4. Bennett, L. M.; Montgomery, J. L.; Collins, N. K.; Steinberg, S. M.; and Kulp, K. S. (2011) "Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model," Journal of Complementary and Integrative Medicine: Vol. 8: Iss. 1, Article 21. DOI: 10.2202/1553-3840.1157
  5. E.S.F. Berman, S.L. Fortson, K.S. Kulp, “Preparation of single cells for imaging mass spectrometry” in S.S. Rubakhin, J.V. Sweedler (eds.), Mass Spectrometry Imaging, Methods in Molecular Biology 656, pp 253-265 DOI 10.1007/978-1-60761-746-4_15, © Springer Science+Business Media, LLC 2010

 

Selected publications:

  1. K.W. Nettles, J.B. Brunin, G. Gil, J. Nowak, S. K Sharma, J. B Hahm, K. Kulp, R. B Hochberg, H. Zhou, J.A. Katzenellenbogen, B.S. Katzenellenbogen, Y. Kim, A. Joachimiak, & G. L Greene, NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses, Nature Chemical Biology 4, 241 - 247 (2008)
  2. L.Wu, X.Lu, K.S. Kulp, M.G. Knize, E.S.F. Berman, E.J. Nelson, J.S. Felton, K.J. Wu (2007)“Imaging and differentiation of mouse embryo tissues by ToF-SIMS” International Journal of Mass Spectrometry, 260:137-145.
  3. E.S.F. Berman, K.S. Kulp, M.G. Knize, L.Wu, E.J. Nelson, D.O. Nelson, K.J. Wu (2006), Distinguishing Monosaccharide Stereo- and Structural Isomers with ToF-SIMS and Multivariate Statistical Analysis” Analytical Chemistry, 78:6497-6503.
  4. K.S. Kulp, E.S.F. Berman, M.G. Knize, D.L. Shattuck, E.J. Nelson, L. Wu, J.L. Montgomery, J.S. Felton and K.J. Wu (2006), “Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry (TOF-SIMS)” Analytical Chemistry, 78:6351-6358.
  5. K.S. Kulp, J.L. Montgomery, D.O. Nelson, B. McLimans, E.R.Latham, D.L. Shattuck, D.M. Klotz, and L.M. Bennett (2006) “Essiac® and Flor-Essence® herbal tonics stimulate the in vitro growth of human breast cancer cells” Breast Cancer Research and Treatment, 98:249-259.
  6. B.J. Bennion, M. Cosman, F.C. Lightstone, M.G. Knize, J.L. Montgomery, L.M. Bennett, J.S. Felton, K.S. Kulp (2005) “PhIP Carcinogenicity in Breast Cancer: Computational and Experimental Evidence for Competitive Interactions with Human Estrogen Receptor” Chemical Research Toxicology 18:1528-1536.
  7. L.M. Bennett, J.M. Montgomery, S.M. Steinberg, K.S. Kulp, (2004) “Flor-Essence® Herbal Tonic promotes mammary tumor development in Sprague Dawley rats” Breast Cancer Research and Treatment, 88:87-93.
  8. J.S. Felton, M.G. Knize, L.M. Bennett, M.A. Malfatti, M.E. Colvin, K.S. Kulp, (2004) “Impact of Environmental Exposures on the Mutagenicity/Carcinogenicity of Heterocyclic Amines” Toxicology, 198:135-145.
  9. K.S. Kulp, M.G. Knize, N. Fowler, C.P. Salmon, and J.S. Felton, (2004) “PhIP metabolites in human urine after the consumption of well-cooked chicken”. Journal of Chromatography B, 802: 143-153.
  10. K.S. Kulp, S.L. Fortson, M.G. Knize and J.S. Felton, (2003) “An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix.” Food and Chemical Toxicology, 41:1701-1710.
  11. J.S. Felton, M.G. Knize, C.P. Salmon, M.A. Malfatti, and K.S. Kulp.  (2002)“Human Exposure to Heterocyclic amine Food Mutagens/ Carcinogens: Relevance to Breast Cancer”. Environmental and Molecular Mutagenesis, 39:112-118
  12. Kulp, K.S., Knize, M.G., Malfatti, M.A., Salmon, C.P. and Felton, J.S. (2000) "Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) following consumption of a single cooked chicken meal in humans".  Carcinogenesis, 21:2065-2072.
  13. Malfatti, M. A., K. S. Kulp, M.G. Knize, C. Davis, J. P. Massengill, S. Williams, S. Nowell, S. MacLeod, K. Dingley, K. W. Turteltaub, N. Lang, Felton, J.S. (1999). "The identification of [2-14C]2-amino-1-methyl-6-imidazo[4,5-b]pyridine in humans". Carcinogenesis  20, 705-713.